Insulin Resistance & Obesity Make You Sick, Vulnerable to Infections

Ben Bikman, PhD, author of the book “Why We Get Sick,” says we have to address the underlying metabolic health issues making people more vulnerable to infections.

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//Today’s Show //

Learn how improving your metabolic health can decrease your vulnerability to infectious disease!

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—————————————–Show Notes————————————–

11:30 Insulin is a hormone that elicits actions in every cell of your body.
12:12 Fat cells will divide, rather than become insulin resistant.
13:15 Chronic insulin resistance is not solely based upon insulin.
15:30 88% of Americans have at least one aspect of metabolic/insulin resistance syndrome.
16:30 The 5 aspects of metabolic syndrome: high glucose, high waist circumference, high blood pressure, low HDL, and high triglycerides.
19:30 If your HDL to Triglyceride ratio is 1.5 or greater, you are insulin resistant, even if you feel and look lean
23:25 Low glucose does not mean low insulin.
24:21 Bumping up insulin with drugs (insulin therapy) lowers glucose, but forces beta cells to make more insulin.
26:08 You only need supplementary insulin if you are a true tested type 1 diabetic.
26:35 Metformin is a GLP1 agonist. GLP1 is an insulin secretagogue, inducing insulin release.
28:14 Insulin deficiency is uncommon in type 2 diabetics.
33:51 Ceramides, a type of fat, directly antagonize insulin signaling. Ceramides block a cells response to insulin.
35:25 Insulin lowers more on a low carb diet than any other intervention.
36:59 EPA and DHA levels indicate nutritional status.
37:55 ALA/ alpha linolenic acid is the most oxidized and thus the most ketogenic of all the long chain fats, rapidly converting to ketones to be used in the brain as fuel.
39:24 Flax and chia seeds, not the oil, has a place in the diet, especially for children. They need ketones for brain development.
43:12 One meal a day fasting can lead to over eating.
47:14 Hormones dictate energy use in the body.
50:10 Metabolic rate is the sum of every chemical reaction that happens in the body. Insulin slows metabolic rate and ketones, influenced by hormones, speed metabolic rate.
54:55 Insulin is at the root of PCOS.
58:27 Insulin factors in the male erection. Insulin facilitates vasodilation through nitric oxide. In ED, capillaries have become insulin resistant and insulin cannot make as much nitric oxide to induce dilation.
59:48 You cannot have insulin resistance without hyperinsulinemia.
01:02:36 Decades before Alzheimer’s is detected clinically, there is a detectible brain/glucose hypometabolism. It is an energy deficiency in the brain.
01:09:00 Studies are showing that the failing heart uses more ketones for fuel. Ketones induce a more forceful contraction of the heart.
01:19:20 Fat cells are among the highest expressors of ACE2. It is suspected that the ACE2 protein facilitates the COVID19 virus infection of cells.
01:21:11 Adipocytes make more of this PIA than any other cell in the body. Plasminogen activator inhibitor (PAI) is an implicated protein in a cytokine storm. It blocks blood clot breakdown. Blood clots are thought to be one of the leading causes of mortality with COVID19 infections.
01:27:10 3 Pillars to Reverse/Slow Insulin Resistance: Control carbohydrates, prioritize (animal) protein, and fuel with fat. Include fasting.
01:29:23 Adding fat to protein, helps protein work better.