Choline – Part 2 – choline dosage

TODAY WITH GUY RAZI:

You might be wondering why a second choline video?

We got a lot of questions concerning choline and decided to make a second video to address some issues.

So, to reiterate, choline is processed in the mitochondria to make acetylcholine which can then drive various cellular processes.

Among them, cognition and memory.

Having more fuel does not inherently make you have a better car.

Choline is generally available in food sources.

You only need to supplement with extra choline if you are taking a supplement that promotes the use of choline in mitochondria.

The 2 forms of choline generally taken in supplemental form when a racetam is present are Alpha-GPC and CDP-Choline. Alpha-GPC has been noted to reduce cognitive decline and improve power output.

It can help slow the progress of Alzheimer’s disease.

There is some evidence that it protects the brain if given immediately following a stroke. L-alpha-glycerylphosphorylcholine is a choline containing a phosphlolipid, allowing it to pass into fat soluble areas. The choline becomes acetylcholine while the lipid becomes glycerophosphate. Ingesting in excess of 1000mg/kg seems to be the cut off but this is rather high, most racetams supplement choline in the 1g range.

CDP-Choline, citicholine, is a choline molecule and a cytidine molecule.

CDP-Choline increases attention and memory.

It slows cognitive decline.

It has evidence of helping to deal with withdrawal from addictive substances. There is some evidence that it reduces pain perception.

It also helps with stroke recovery.
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Source: Choline – Part 2 – choline dosage